Functional cytology of bovine adenohypophysis and the effects of mestranol and chlormadinone acetate
Schuffenhauer, W.; Lange, W.
Archiv für Experimentelle Veterinarmedizin 28(5): 749-758
1974
ISSN/ISBN: 0003-9055 PMID: 4142925 Document Number: 75207
The synthetic oestrogen mestranol, given by mouth to young bulls, appeared to stimulate chromophobe cells of the anterior lobe of the pituitary, indicating stimulation of ACTH secretion. The mass of the pituitary was also increased by administration of 5 mg mestranol daily for 130 days. This hypertrophy was prevented by a single intramuscular injection of chlormadinone acetate. The anterior epithelium of the hypophyseal cavity reacted tooestrogen administration by increased secretory activity.