Protein expression of hMSH2 and hMLH1 in HNPCC: evaluation of a prescreening method
Vossen, S.; Möslein, G.; Katzer, M.; Gabbert, H.E.; Müller, W.; Wirtz, C.; Goretzki, P.E.; Röher, H.D.
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 115: 1461-1463
1998
ISSN/ISBN: 0942-2854 PMID: 9931912 Document Number: 7441
We show that immunohistochemistry for hMSH2 and hMLH1 is an easy and reproducible routine procedure. The interpretation of the staining results is unequivocal and investigator-independent. It is now necessary to validate the specificity and sensitivity of the method in a multicenter study with tumors of known mutations. As a consequence perhaps MIN testing may be replaced by immunohistochemistry as a first-line pretesting for HNPCC, reducing cost and time required.
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