Expression and clinical significance of p27 protein and cyclinD1 protein in gastrointestinal stromal tumors
Yang, X.-d.; Zuo, M.; Pan, K.
Zhonghua Yi Xue Za Zhi 85(19): 1352-1354
2005
ISSN/ISBN: 0376-2491 PMID: 16029637 Document Number: 587758
To investigate the expression of p27 and cyclin D1 protein in gastrointestinal stromal tumors (GIST), and discuss the relationship between their expression and clincopathological characteristics. Immunohistochemical staining was used to detect the expression of p27 and cyclin D1 in 48 cases of GIST and corresponding normal tissues. In 48 cases GIST, the expression of p27 and cyclin D1 protein were 54.16% and 58.33% respectively. The low level expression of p27 protein was inversely correlated with the degree of differentiation and tumor recurrence of GIST (both P < 0.01). The expression of p27 protein was positively relatied to that of cyclin D1 (r = 0.573, P < 0.01). These data shows the expression of p27 and cyclin D1 expression are related to the ontogenesis and progression of GIST. p27 and cyclin D1 may be prognostic indicators in GIST.