Parenteral formulations of small molecules therapeutics marketed in the United States (1999) --Part i
Strickley, R.G.
PDA Journal of Pharmaceutical Science and Technology 53(6): 324-349
1999
ISSN/ISBN: 1079-7440 PMID: 10754732 Document Number: 7286
The chemical structure of a molecule determines the potential successful formulation approaches available to the parenteral scientist. However, there is no comprehensive listing of parenteral products with the chemical structure and formulation. A review of domestically marketed injectable product formulations of small molecule therapeutics is presented herein with the intent of compiling a comprehensive source of public information for the formulation scientist. The compilation lists the drug name, marketed name, chemical structure of the drug, marketed injectable formulation, preadministration preparation, route of administration, company and the clinical indication. One purpose of this compilation is to assist the formulation scientist in being able to look at a drug's chemical structure and then be able to determine possible formulation approaches. This compilation will also be useful for those interested in knowing what additives are currently used in injectable products and at what concentrations they are administered in practice. This compilation only focuses on marketed formulations and does not delve into the subject of preclinical or drug discovery formulations associated with early-stages pharmacokinetics or proof-of-concept pharmacodynamics, where the formulation scientist is not bound by regulatory constraints.
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