The cardiology and endocrinology connection between amiodarone and thyrotoxicosis: case report and review of the literature
Palermo-Garófalo, C.; Martínez, Jé.Hernán.; Silva, F.; González, E.; Torres, O.; Figueroa, J.; González, Jé.; de Lourdes, M.María.
Boletin de la Asociacion Medica de Puerto Rico 105(2): 47-53
2013
ISSN/ISBN: 0004-4849 PMID: 23882990 Document Number: 702635
Amiodarone is used in a large number of cardiac conditions. Amiodarone-induced thyroid dysfunction has been reported to affect up to 20% of users. Amiodarone can lead to both amiodarone-induced hypothyroidism (AIH) and less commonly amiodarone-induced thyrotoxicosis (AIT). There are two main forms of AIT. Type 1 AIT, a form of io-dine-induced hyperthyroidism, and type 2, a drug-induced destructive thyroiditis. Type 1 AIT develops on individuals with underlying thyroid disease. Treatment of Type 1 AIT includes the use of antithyroid drugs and discontinuation of amiodarone. Type 2 AIT is commonly self-limiting in nature. In this article wedescribe a patient with Amiodarone-induced thyrotoxicosis discussing its clinical features and medical therapeutic approach.
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