An unexpected side-effect of a commonly used drug
Fernández González, F.; Miranda, S.; Santiago Casiano, M.ón.; Nieves, J.é; Adorno, E.; Fernández González, R.
Boletin de la Asociacion Medica de Puerto Rico 105(3): 50-52
2013
ISSN/ISBN: 0004-4849 PMID: 24282922 Document Number: 702305
We report a case of a 68 year-old-female patient with clinical features of drug-induced lupus erythematosus after five years of treatment with amiodarone. She presented generalized skin rash, arthralgia on upper and lower extremities, associated with difficulty to walk. Remarkable laboratory results revealed a positive antinuclear antibody test and a skin rash biopsy showing a superficial and deep perivascular infiltrate of lymphocytes, histiocytes, and eosinophils. Once the etiology of the patient's symptoms was identified, the culprit drug was removed and she had a complete remission of all signs and symptoms. Early diagnose should be recognized for prompt intervention and avoid further complications associated with this rare side-effect.
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