Pancreatitis vs. rejection in human pancreatic transplantation: unresolved pathological findings
Toledo-Pereyra, L.H.; Baxter, J.R.; Choudhury, S.; Mittal, V.K.
Boletin de la Asociacion Medica de Puerto Rico 74(5-6): 172-175
1982
ISSN/ISBN: 0004-4849 PMID: 6758806 Document Number: 701264
The pathological findings of live transplanted pancreas allografts are discussed in this work. Chronic rejection and pancreatitis were the main findings seen in this group of pancreases. Arterial and venous thrombosis, interlobular and perilobular fat necrosis, interlobular and perilobular fibrosis with round cell infiltration, and intimal sickening were common findings. Acute and chronic inflammatory cells were noted in all the specimens obtained several weeks post-transplantation. The differential diagnosis of rejection and chronic pancreatitis was difficult without the clinical history. In general, rejection changes were present in all specimens, and chronic pancreatitis was associated with rejection only in the specimens obtained several weeks (more than four) after transplantation. The study of these pathological specimens offer some help in the better understanding of the acute and chronic changes occurring after pancreatic transplantation. Also, it would allow for early recognition of the immunological pancreatic allograft response at various intervals after transplantation.
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