Characterization of the antitumor activity of a polyantigenic immunomodulator (PAI) : I--Utilization of cimetidine and cyclosporine a
Ríos-Olivares, E.; Orraca, Z.M.; Carrasco-Canales, J.A.; Alvarado, L.; Marchand, A.M.; Colón, J.I.
Boletin de la Asociacion Medica de Puerto Rico 81(7): 246-253
1989
ISSN/ISBN: 0004-4849 PMID: 2789052 Document Number: 700305
Cimetidine (CMT), cyclosporine A (CsA), interleukin 2 (IL 2), were used to characterize the anticancerous effect of a polyantigenic immunodulator (PAI). PAI consists of a mixture of inactivated bacteria and influenza virus in a peanut oil-arlacel A-aluminum monoesterate emulsion. Antitumoral activity was tested on Ehrlich's ascites tumor (EAT) implanted into Swiss-Webster (allogeneic) or C57BL/6J (syngeneic) mice. PAI antitumor activity was enhanced by CMT acting synergistically by reducing substantially the tumor growth and increasing the percentage of surviving mice, while CsA suppressed this activity. PAI or its individual components were able to induce significant lymphocyte blastogenesis in mouse (C57BL/6J)-spleen lymphocytes and IL-2 enhanced considerably this lymphoproliferative response. The results suggest that PAI acts at the level of cellular immunity.
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