Pressurised intraperitoneal aerosol chemotherapy (PIPAC) for the treatment of peritoneal metastases
Graversen, M.; Detlefsen, S.ön.; Knudsen, A.Ør.; Pfeiffer, P.; Mortensen, M.B.
Ugeskrift for Laeger 181(20a)
2019
ISSN/ISBN: 1603-6824 PMID: 31610840 Document Number: 698848
Pressurised intraperitoneal aerosol chemotherapy (PIPAC) was introduced in Denmark in 2015. More than 100 Danish patients with peritoneal metastases (PM) have received PIPAC-directed treatment within the PIPAC-OPC1 and PIPAC-OPC2 trials. PIPAC-directed treatment is feasible and safe, and there are no occupational risks for the involved healthcare professionals. An objective tumour response is seen in two out of three patients, and the survival data warrant further evaluation in large-scale randomised trials in patients with PM from different primary tumours.
Document emailed within 1 workday
Related Documents
Lepistö, A. 2016: Novel approved form of treatment for colonic cancer with peritoneal metastases - radicality-aimed surgery combined with hyperthermic intraperitoneal chemotherapy Duodecim; Laaketieteellinen Aikakauskirja 132(10): 912-916Youngchaiyud, P.; Charoenratanakul, S. 1987: Terbutaline pressurised aerosol inhaled via a Nebuhaler--an effective alternative to subcutaneous adrenaline for treatment of acute severe asthma European Journal of Respiratory Diseases 70(5): 284-292
Mahteme, H.; Påhlman, L. 2005: Treatment of peritoneal surface malignancy by peritonectomy and intraperitoneal chemotherapy: a novel therapy with curative potential! Minerva Chirurgica 60(3): 151-157
Robella, M.; Vaira, M.; Marsanic, P.; Mellano, A.; Borsano, A.; Cinquegrana, A.; Sottile, A.; De Simone, M. 2014: Treatment of peritoneal carcinomatosis from ovarian cancer by surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) Minerva Chirurgica 69(1): 27-35
Zoetmulder, F.A.; van der Vange, N.; Witkamp, A.J.; Kaag, M.M.; Boot, H.; Beijnen, J.H. 1999: Hyperthermic intra-peritoneal chemotherapy (HIPEC) in patients with peritoneal pseudomyxoma or peritoneal metastases of colorectal carcinoma; good preliminary results from the Netherlands Cancer Institute Nederlands Tijdschrift Voor Geneeskunde 143(37): 1863-1868
Yonemura, Y.; Endou, Y.; Tochiori, S.; Bando, E.; Kawamura, T.; Shimada, T.; Miyamoto, K.-i.; Tanaka, M.; Sasaki, T. 2005: Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 32(11): 1635-1639
Sideris, L.; Mitchell, A.; Drolet, P.; Leblanc, G.; Leclerc, Y.E.; Dubé, P. 2009: Surgical cytoreduction and intraperitoneal chemotherapy for peritoneal carcinomatosis arising from the appendix Canadian Journal of Surgery. Journal Canadien de Chirurgie 52(2): 135-141
Mansvelt, B.; Bertrand, C.; Nockerman, P.; Arnould, P.; Delvaux, P.; Lechien, X.; de Neve de Roden, A. 1997: Study of the toxicity and results of intraperitoneal hyperthermic chemotherapy in 28 patients with peritoneal carcinomatosis Annales de Chirurgie 51(1): 60-67
Arai, K.; Iwasaki, Y.; Kimura, Y.; Takahashi, K.; Yamaguchi, T.; Takahashi, T. 2002: Studies of the effectiveness and optimal administration of repeated intraperitoneal chemotherapy for peritoneal dissemination from gastric cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 29(12): 2160-2163
Ben-Yaacov, A.; Nevo, Y.; Nissan, A. 2019: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (Hipec) for Peritoneal Metastasis of Gastro-Intestinal Origin Harefuah 158(4): 263-267
Iwamoto, A.; Takahashi, T.; Sasabe, T.; Itoh, M.; Kondoh, S.; Seiki, K.; Yoneyama, C.; Shimotsuma, M.; Hagiwara, A.; Yamaguchi, T. 1989: Intraoperative chemotherapy with intraperitoneal activated carbon particles adsorbing mitomycin C against peritoneal dissemination of gastric cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(8 Pt 2): 2748-2751
Yamaguchi, S.; Asao, T.; Tsutsumi, S.; Fujii, T.; Yamauchi, H.; Kigure, W.; Morita, H.; Yajima, R.; Suto, T.; Kuwano, H. 2011: Effectiveness of intraperitoneal hyperthermo-chemotherapy for malignant peritoneal mesothelioma and estimation of its effect by repeated FDG-PET: a case report Hepato-Gastroenterology 58(107-108): 861-864
Xia, W.; Hu, Y.; Mou, T.; Chen, T.; Yu, J.; Li, G. 2014: Safety and efficacy of intraperitoneal hyperthermic perfusion chemotherapy following laparoscopic palliative resection for gastric cancer patients with peritoneal metastasis Zhonghua Wei Chang Wai Ke Za Zhi 17(11): 1087-1091
Huo, Y.Ruth.; Huang, Y.; Liauw, W.; Zhao, J.; Morris, D.L. 2016: Prognostic Value of Carcinoembryonic Antigen (CEA), AFP, CA19-9 and CA125 for Patients with Colorectal Cancer with Peritoneal Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy Anticancer Research 36(3): 1041-1049
Ohashi, N.; Kodera, Y.; Nakanishi, H.; Yokoyama, H.; Fujiwara, M.; Koike, M.; Hibi, K.; Nakao, A.; Tatematsu, M. 2005: Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice International Journal of Oncology 27(3): 637-644
Nikolic, S.; Dzodic, R.; Zegarac, M.; Djurisic, I.; Gavrilovic, D.; Vojinovic, V.; Kocic, M.; Santrac, N.; Radlovic, P.; Radosavljevic, D.; Pupic, G.; Martinovic, A. 2014: Survival prognostic factors in patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy: a single institution experience Journal of BUON: Official Journal of the Balkan Union of Oncology 19(1): 66-74
Ciaccio, V.; Bufalari, A.; Ferri, M.; Giustozzi, G.M. 1992: Totally implantable systems in colorectal tumors. the locoregional chemotherapy of hepatic and peritoneal metastases Minerva Chirurgica 47(7): 621-625
Sato, M.; Ishidoya, T.; Joko, Y.; Kiyasu, Y.; Sakai, K.; Kimura, S. 1984: Constant intra-aortic infusion chemotherapy for advanced abdominal cancer--a technic and the effect in patients with peritoneal metastases Gan no Rinsho. Japan Journal of Cancer Clinics 30(7): 805-809
Sherman, A.I.; Rosenberg, R.; Fink, D. 1992: Use of intraperitoneal chemotherapy for treatment of ovarian cancer European Journal of Gynaecological Oncology 13(4): 295-305
Moberly, J.B.; Sorkin, M.; Kucharski, A.; Ogle, K.; Mongoven, J.; Skoufos, L.; Lin, L.; Bailey, S.; Rodela, H.; Mupas, L.; Walele, A.; Ogrinc, F.; White, D.; Wolfson, M.; Martis, L.; Breborowicz, A.; Oreopoulos, D.G. 2003: Effects of intraperitoneal hyaluronan on peritoneal fluid and solute transport in peritoneal dialysis patients Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 23(1): 63-73