Serious S-1-Induced Lung Injury Diagnosed by Early Lung Biopsy-A Case Report
Kobayashi, Y.; Taniuchi, N.; Shimizu, M.; Murata, Y.; Gemma, A.; Hirose, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 46(9): 1457-1460
2019
ISSN/ISBN: 0385-0684 PMID: 31530790 Document Number: 698769
The patient was a 65-year-old man who developed dyspnea after 6 courses of S-1 and oxaliplatin(SOX)chemotherapy for advanced stomach cancer. The chemotherapy regimen consisted of SOX chemotherapy. The patient developed hypoxemia, and chest radiography revealed ground-glass opacity in both lungs. Bronchoscopy and DLST led to a diagnosis of druginduced lung injury caused by S-1. Although steroid pulse therapy was administered, the patient's condition deteriorated rapidly and was ultimately fatal. Based on the clinical course and histopathological findings, a DAD-type lung disorder was diagnosed. This description of a DAD-type drug-induced lung injury caused by S-1, for which histopathological findings were available in the early stages, is clinically valuable. We report this case along with a review of the relevant literature.