Incidence of Catheter-Related Thrombosis in Patients with Long-Term Indwelling Central Venous Port who Received Chemotherapies for Unresectable Advanced Digestive Cancers
Tanioka, H.; Asano, M.; Kawasaki, K.; Yoshida, R.; Waki, N.; Uno, F.; Ishizaki, M.; Yamashita, K.; Katata, Y.; Sano, F.; Okawaki, M.; Yamamura, M.; Nagasaka, T.; Yamaguchi, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 46(13): 2182-2184
2019
ISSN/ISBN: 0385-0684 PMID: 32156872 Document Number: 698554
Most patients with unresectable advanced digestive cancers require placement of a fully implantable venous access port to facilitate safe delivery of anti-cancer drugs. Anti-VEGF therapies are commonly used even though they increase the risk of thrombosis. The objective of this study was to assess the incidence of radiologically confirmed catheter-related thrombosis(CRT)in patients with advanced digestive cancers. We retrospectively reviewed 88 patients with advanced digestive cancers who had adapted implantable ports placed in our institution for chemotherapy. Thirty-nine patients were diagnosed with colorectal cancer, 26 with gastric cancer, 12 with pancreatic cancer, 8 with esophageal cancer, and 3 with other cancers. During follow-up, 22 patients(25%)received anti-VEGF therapies, while 66 patients(75%)did not. Four out of 88 patients(4.5%)had asymptomatic CRT. The incidence of CRT was the same(4.5%)regardless of whether the patient received anti-VEGF therapy. In patients with digestive cancers who had implantable venous access ports, the incidence of the CRT was 4.5% with no association with anti-VEGF therapies.