Long-term outcome of advanced hepatocellular carcinoma that received transarterial hepatic chemotherapy
Masutani, S.; Shimizu, J.; Tatsuta, M.; Masuda, F.; Imamura, H.; Ishida, H.; Furukawa, H.; Tomotsu, K.; Yura, M.; Obana, T.; Kitamura, S.; Saeki, N.; Inoue, Y.; Takamura, M.; Ohnishi, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 30(11): 1579-1582
2003
ISSN/ISBN: 0385-0684 PMID: 14619468 Document Number: 556378
Nineteen patients with far advanced hepatocellular carcinoma received transarterial hepatic chemotherapy. Twelve patients were Child-Pugh A, 2 were B, and 2 were C. Seventeen patients had portal vein thrombus, and 2 patients had extra-hepatic metastasis. Among the 19 patients, 13 received low-dose CDDP and 5-FU, and 5-FU with interferon was performed in 2. Lipiodol chemotherapy with epirubicin and MMC was performed after first-line chemotherapy, following the evaluation of the progressive disease. The 1- and 3-year survival rates in all cases were 42.5% and 18.2%, respectively. Of the 18 patients evaluated for response, 1 showed complete response, 2 showed partial responses, 8 had stable disease, and 7 progressed. Median survival time of CR, PR and SD patients was 14.2 months. A multivariate analysis identified CLIP score and therapeutic effect as independent predictors for mortality. It is concluded that transarterial hepatic chemotherapy was very useful for far advanced hepatocellular carcinoma.