An Approach to the Pharmacotherapy of Neuroleptic Malignant Syndrome
Van Rensburg, R.; Decloedt, E.H.
Psychopharmacology Bulletin 49(1): 84-91
2019
ISSN/ISBN: 0048-5764 PMID: 30858642 Document Number: 698000
Neuroleptic malignant syndrome is a rare, idiosyncratic emergency associated with exposure to dopamine antagonists, commonly antipsychotic drugs. The typical clinical picture consists of altered consciousness, muscular rigidity, fever, and autonomic instability. While the condition has generally been well described, the pathophysiology is still poorly understood. The importance of this case report is to highlight the lack of robust evidence-based treatment for this emergency. We submit an approach to the pharmacotherapy of neuroleptic malignant syndrome based on the available evidence.