“The higher the better” seems to be no longer true for HDL-cholesterol
Rosolová, H.
Vnitrni Lekarstvi 64(12): 1153-1155
2019
ISSN/ISBN: 0042-773X PMID: 30704250 Document Number: 697914
It is very well known from the old epidemiological population studies, that HDL-cholesterol (HDL-C) was in a negative association with coronary events risk. New studies have occurred during the last 10 years that the mentioned association has in fact the U-shaped curve, i.e. lower and higher levels of HDL-C then the optimal one are in an exponential increasing risk. The association of high HDL-C levels with cardiovascular risk is not explained clearly. There might be a hypothesis concerning a change of function of large HDL particles riched of cholesterol esters, which become to be cholesterol donors for the arteries. Key words: cardiovascular risk - HDL-cholesterol - HDL particles.