DNA repair genes: contributions to prostate cancer predisposition and aggressiveness
Boyle, J.; Cooney, K.A.
Canadian Journal of Urology 26(5 Suppl 2: 10-11
2019
ISSN/ISBN: 1195-9479 PMID: 31629416 Document Number: 697813
Germline pathogenic mutations in DNA repair genes have been linked to prostate cancer risk and aggressiveness. This observation was facilitated by tumor sequencing of men with advanced prostate cancer and has important implications for clinical management. In addition, cascade testing will identify at-risk individuals who should be assessed for cancer risk.
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