Two Cases of Locally Recurrent Rectal Cancer Successfully Treated by Carbon Ion Radiotherapy
Kanehara, K.; Ohnuma, S.; Suzuki, H.; Yamamura, A.; Karasawa, H.; Kohyama, A.; Aoki, T.; Watanabe, K.; Tanaka, N.; Musha, H.; Motoi, F.; Kamei, T.; Naitoh, T.; Unno, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 45(13): 1940-1942
2018
ISSN/ISBN: 0385-0684 PMID: 30692404 Document Number: 697744
Case 1: A female patient in her 60s underwent laparoscopic intersphincteric resection for rectal cancer. After 42 months, the serum level of carcinoembryonic antigen(CEA)was elevated, and PET-CT showed a locally recurrent rectal cancer that increased FDG-uptake. Carbon ion radiotherapy(CIRT)(73.6 GyE/16 Fr)was performed. Serum CEA level and FDG-uptake were normalized. No regrowth of tumor has been found for 12 months. Case 2: A female patient in her 60s underwent abdominoperineal resection for rectal cancer. After 42 months, the serum level of CEA was elevated, and CT revealed a local recurrence of rectal cancer. Subsequently, the tumor was resected; however, resection margin was microscopically positive. Therefore, chemoradiotherapy(S-1, 60 Gy)was performed. At 31 months after local resection, a re-recurrent tumor was noted in her left ischium. Therefore, CIRT(70.4 GyE/16 Fr)was performed. Serum CEA level and FDG-uptake were normalized. No regrowth of tumor has been found for 24 months. CIRT is an effective therapy for locally recurrent rectal cancer.