Reaccion acneiforme noduloquistica secundaria a vemurafenib con buena respuesta a isotretinoina oral Severe acneiform eruption associated with vemurafenib with response to isotretinoin
Elosua-Gonzalez, M.; Lopez-Estebaranz, J.L.; Garcia-Zamora, E.; Vela-Ganuza, M.; Rodrigez-Vasquez, X.
Dermatology Online Journal 24(8)
2018
ISSN/ISBN: 1087-2108 PMID: 30677858 Document Number: 697518
Vemurafenib, a kinase inhibitor that targets tumors with the BRAF V600E mutation, is a promising option for unresectable or metastatic melanoma. Cutaneous side-effects have been reported including alopecia, photosensitivity, squamous cell carcinoma, keratoacanthomas, keratosis pilaris-like eruption, and palmoplantar hyperkeratosis. Acneiform eruptions have been reported in 3%-6% of the patients treated with BRAF inhibitors,and 5 cases are described in the literature. Although they responded well to topical therapies, oral antibiotics, or observation, one case required oral etretinate and the withdrawal of vemurafenib because the adverse event reached grade 3. We report one case of a severe acneiform eruption associated with vemurafenib with a good response to isotretinoin allowing continuation of the BRAF inhibitor.