Cutaneous manifestations of vemurafenib therapy for metastatic melanoma
Owen, J.L.; Lopez, I.E.; Desai, S.R.
Journal of Drugs in Dermatology Jdd 14(5): 509-510
2015
ISSN/ISBN: 1545-9616 PMID: 25942671 Document Number: 684093
Vemurafenib, a BRAF inhibitor, is FDA-approved for the treatment of metastatic melanoma in patients who harbor the BRAF V600E mutation. By inhibiting BRAF, vemurafenib prevents the mitogen-activated protein kinase (MAPK) pathway from driving melanoma growth. Here we present a patient with paradoxical activation of the MAPK pathway by vemurafenib, ultimately resulting in deleterious cutaneous manifestations. An emphasis on close follow-up is warranted for new or changing lesions for patients on this medication and other BRAF inhibitors.
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