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Drug-target network of taxanes revealed by data mining

Chen, S-Jun.; Wei-Cai, -.; Li, Z-Hui.

Pakistan Journal of Pharmaceutical Sciences 31(2): 485-489

2018

ISSN/ISBN: 1011-601X
PMID: 29618439
Document Number: 697242
Taxanes, mainly group paclitaxel and docetaxel, are amongst the most promising anticancer agents that are widely used for a variety of tumor types. It is a great challenge to gain a quick overview of the molecular mechanisms of taxanes, owning to the massive amounts of data have been produced. Network pharmacology will be a powerful tool to uncover the drug-targets network of taxanes. In this study, drug-targets network of paclitaxel and docetaxel were constructed via STITCH by database mining, and its topological parameters and important nodes were analyzed. All will provide a systematic understanding for molecular mechanisms of pacltaxel and docetaxel in a quick and visual way.

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