Polycyclic annular presentation of pemphigus vulgaris with an eosinophil predominance in two pregnant patients
Küçükoğlu, Rıfkiye.; Sun, G.Pınar.; Kılıç, Sıla.
Dermatology Online Journal 24(10)
2018
ISSN/ISBN: 1087-2108 PMID: 30677814 Document Number: 696719
Pemphigus during pregnancy has a more complicated course owing to the limitations in treatment options and alterations in the severity and presentation of the clinical features. We would like to present two pemphigus vulgaris (PV) cases associated with pregnancy with an unusual clinical appearance exhibiting polycyclic, annular, vesiculobullous plaques with marked eosinophil infiltration in histopathology. To the best of our knowledge pregnancy-associated pemphigus cases with this particular clinical presentation have not been reported in the literature. Changes in the immunologic and hormonal state during pregnancy may play a role in altering the classic clinical presentation and treatment response of PV.