An unusual presentation of Amyloidosis AL
Zito, A.; De Pascalis, A.; Ria, P.; Armeni, A.; D'Amelio, A.; Napoli, M.
Giornale Italiano di Nefrologia: Organo Ufficiale Della Societa Italiana di Nefrologia 35(3)
2018
ISSN/ISBN: 0393-5590 PMID: 29786185 Document Number: 696384
We describe the case of a 74-year-old man admitted to our Nephrology Unit with nephrotic syndrome and mild kidney disease. A complete panel of laboratoristic and instrumental tests did not provide useful information for diagnosis. No specific signs or symptoms suggested the presence of AL amyloidosis. As a matter of fact, diagnosis was reached thanks to the hystopathologic examination of renal tissue and bone marrow, since the associated B-cell lymphoproliferative disorder had not revealed itself through serum and urine electrophoresis and immunofixation. This recent case provides the opportunity to review about the disease and to revaluate the renal biopsy as a first line exam in a clinical context where laboratoristic and instrumental tests offer us poor information.