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Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags

Breukels, O.; van der Gronde, T.; Simons-Sanders, K.; Crul, M.

International Journal of Pharmaceutical Compounding 22(4): 345-349

2018

ISSN/ISBN: 1092-4221
PMID: 30021191
Document Number: 696310
Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs.

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