Short- and Long-Term Effects of a Dentifrice Containing Dual Zinc plus Arginine on Intra-Oral Halitosis: Improvements in Breath Quality
Saad, S.; Fitzgerald, M.; Hewett, K.; Greenman, J.; Vandeven, M.; Trivedi, H.M.; Masters, J.G.
Journal of Clinical Dentistry 29(Special Issue A): A46-A54
2018
ISSN/ISBN: 0895-8831 PMID: 30620871 Document Number: 696246
These studies aimed to assess the short-term (12-hour, single use) and long-term (four weeks, continuous use) efficacy of a new Dual Zinc plus Arginine dentifrice against intra-oral halitosis versus a negative control. Two clinical studies were conducted to assess the dentifrice: a four-week, continuous use parallel design versus a negative control and a single use crossover design versus a negative control. Both studies used organoleptic and hedonic odor judge scores measured 12 hours overnight after product use as the primary efficacy variable. Additionally, the single use study employed SIFT-MS to quantify the intra-oral concentration of volatile sulfur compounds as a complementary measure of efficacy. In both studies, the Dual Zinc plus Arginine dentifrice provided statistically significant improvements in breath quality across all measures versus a negative control. Improvements in breath quality were attributed to the effects of zinc cations delivered by the uniquely formulated dentifrice.