Sheehan's Syndrome-The Most Common Cause of Panhypopituitarism at Moderate Altitude: a Sub-Himalayan Study
Mokta, J.; Ranjan, A.; Thakur, S.; Bhawani, R.; Mokta, K.K.; Sharma, J.B.; Kumar, M.
Journal of the Association of Physicians of India 65(12): 20-23
2017
ISSN/ISBN: 0004-5772 PMID: 29327517 Document Number: 692806
Panhypopituitarism is a rare disorder with varied clinical presentation having various etiologies. Sheehan's syndrome (SS) is decreasing in frequency worldwide and is a rare cause of panhypopituitarism in developed nations. A retrospective study done between May 2011 and May 2015 in tertiary care hospital. We reviewed the records of patients with hypopituitarism. Clinical features, hormonal profile and radiological investigations noted. Total 14 patients of panhypopituitarism included with average duration of symptoms 1.93± 1.96 years. four (28.57%) were males and ten (71.43%) were females with mean age of diagnosis 37.78± 13.68 years. Sheehan's syndrome (SS) was the most common cause of panhypopituitarism in 57.14%(8 patients), followed by post surgery in 14.28% (2 patients). 80% of women had SS with a mean duration of symptoms 2.39±1.54 years. Sheehan's syndrome is not uncommon in developing countries, High degree of clinical suspicion is desired as clinical features are most often subtle.