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Single nucleotide polymorphisms of MIR-149 gene rs2292832 contributes to the risk of hepatocellular carcinoma, but not overall cancer: a meta-analysis

Jia, H.; Yu, H.; Liu, Q.

Minerva Medica 107(4): 259-269

2016

ISSN/ISBN: 0026-4806
PMID: 27348444
Document Number: 690953
Single nucleotide polymorphism in miRNAs can alter its expression, thus can lead to the development of cancers. Numerous studies have explored the association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma (HCC) risk, but the results remains inconsistent. So, we performed this pooled analyses in order to get a precise result. Odds ratios (OR) with 95% confidence intervals (CI), calculated by STATA software, was used to determine whether MIR-149 gene rs2292832 polymorphism contributes to the risk of HCC. A comprehensive literature search was conducted on Medline (mainly PubMed), Cochrane Library database, Web of science and the China National Knowledge Internet (CNKI) up to March 22, 2016. A total of 19 studies including 8201 cases and 9294 controls were included in this meta-analysis. Four of 20 studies related to the HCC risk. When all the eligible studies were pooled into this meta-analysis, a significant association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk was found, while no association was found between this gene polymorphism and overall cancer risk. Our meta-analysis supports that the MIR-149 gene rs2292832 polymorphism contributed to the risk of HCC from currently available evidence. However, a study with a larger sample size is needed to further evaluate gene-environment interaction on MIR-149 gene rs2292832 polymorphism and HCC risk.

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Jia, H.; Yu, H.; Liu, Q. 2016: Single nucleotide polymorphisms of miR-149 gene rs2292832 contributes to the risk of hepatocellular carcinoma, but not overall cancer: a meta-analysis Minerva Medica 2016
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