Advances in Researches on the Relations between miRNA-143/miRNA-145 and Colorectal Cancer
Chen, W.; Wang, J.; Ma, Y.; Wang, Y.; Yang, J.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 33(6): 1220-1224
2016
ISSN/ISBN: 1001-5515 PMID: 29715423 Document Number: 690932
Colorectal cancer is one of the most common malignant diseases that threatens human being's health.With researches on microRNAs(miRNAs)getting deeper and wider,more evidences revealed that a great many of miRNAs have been involved in the development of colorectal cancer and have the potential to become the biomarker for early diagnosis,prediction of prognosis and recurrence of colorectal cancer.MiRNA-143/miRNA-145 are significantly reduced in several cancers,including colorectal cancer,showing an antitumorigenic activity.In the present article,we make a brief review on the advances in the researches on miRNA-143/miRNA-145 and colorectal cancer to provide guidance for further explorations of the mechanism and target therapy of this disease.