Lifestyle-related diseases and an inter-organ metabolic network
Miyachi, Y.; Tsuchiya, K.; Ogawa, Y.
Clinical Calcium 26(3): 392-398
2016
ISSN/ISBN: 0917-5857 PMID: 26923976 Document Number: 689927
Lifestyle-related diseases such as type 2 diabetes, hypertension and dyslipidemia are a prominent cause of mortality in Japan, and there is a strong requirement for elucidation of detailed molecular mechanisms and effective therapeutic strategies. Obesity-induced adipose tissue inflammation leads to dysregulation of adipokine production, which can cause lifestyle-related diseases. The interaction of organ systems via endocrine or neural networks is recognized as an important factor in the pathogenesis and promotion of lifestyle-related diseases. Therefore, further investigation for the interaction between adipose tissues and bones can provide new treatment strategies of metabolic bone disorders.