Hibernation, Hypothermia and a Possible Therapeutic "Shifted Homeostasis" Induced by Central Activation of A1 Adenosine Receptor (A1AR)
Tupone, D.; Cetas, J.S.; Morrison, S.F.
Nihon Shinkei Seishin Yakurigaku Zasshi 36(2): 51-54
2016
ISSN/ISBN: 1340-2544 PMID: 27333659 Document Number: 689776
The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage.