The effect of ladasten on the activation-induced expression of Fas receptor on T-lymphocytes and their sensitivity to Fas-induced apoptosis
Vakhitova, I.V.; Salimgareeva, M.Kh.; Sibiriak, S.V.; Kurchatova, N.N.; Seredin, S.B.
Eksperimental'naia i Klinicheskaia Farmakologiia 67(5): 34-38
2004
ISSN/ISBN: 0869-2092 PMID: 15559634 Document Number: 566994
The effects of ladasten on the activation-induced expression of Fas-receptor on T-lymphocytes, their sensitivity to Fas-induced apoptosis, and the expression of mitogen-activated ERK1/ERK2 protein kinases have been studied. In the range of concentrations 0.1 - 10 muM, ladasten exhibited a comitogenic effect on the TCR-mediated stimulation of T-lymhocytes ion the peripheral human blood, which was accompanied by an increase in the level of phosphorylated form of ERK-2. At the same time, ladasten virtually did not change the activation-induced expression of Fas-receptor on T-lymphocytes, but reduced the rate of the Fas-induced apoptosis. It was concluded that the immunoprotective effect of ladasten is probably based on a decrease in the rate of Fas-induced apoptosis.