Risk-Factors, Pathogenesis, and Pharmaceutical Approaches for Treatment of Steroid-Induced Bone Infarction of Femoral Head
Wang, F.; Wang, Y.; Hu, N.; Miao, X.
Acta Poloniae Pharmaceutica 73(3): 557-563
2016
ISSN/ISBN: 0001-6837 PMID: 27476272 Document Number: 688220
During first year of steroid usage, osteocyte necrosis and blood vessel blockage may occur, which subsequently may produce steroid-induced bone infarction (SIBI) resulting in painful movement of patient. For treatment of SIBI, pharmaceutical strategy is the basic approach. It involves the use of various pharmacologically active compounds including bisphosphonates, hyperbaric oxygen (HBO), coenzyme Q10, erythropoietin, antihyperlipidemics, anticoagulants, antioxidants, and tissue repair protein. Out of these, there is no pharmaceutical agent that may completely treat this disease because many factors are found to be responsible for SIBI development; therefore, there are multiple biomarkers of this disease. This situation argues for need of new therapeutic agents for SIEB1.