Type 1 diabetes mellitus presenting with diabetic ketoacidosis (DKA) in a neonate
Ahmed, F.; Kazi, G.; Khan, W.
Jpma. Journal of the Pakistan Medical Association 66(8): 1026-1028
2016
ISSN/ISBN: 0030-9982 PMID: 27524542 Document Number: 686846
Neonatal diabetes mellitus (NDM) is a rare manifestation with an incidence of one affected individual among 400000 live births. NDM can be divided into Transient (TNDM) and Permanent (PNDM) types. A significant overlap occurs between both groups, to an extent that TNDM cannot be distinguished from PNDM based solely on clinical features. Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). DKA at diagnosis is more common in young children near the age of five years. Neonatal DKA is a rare occurrence causing it to be missed in the differential diagnosis of neonatal illness and results delay in appropriate management and increase in morbidity and mortality rate.