Interferon and bone
Miyamoto, T.
Clinical Calcium 25(11): 1653-1658
2015
ISSN/ISBN: 0917-5857 PMID: 26503870 Document Number: 685372
Interferon(IFN)α, β and γ were identified, and demonstrated played a crucial role in regulating immune system. Expression of IFN α and β are both promoted by viral infection, and these factors have been utilized to treat the patients with hepatitis C. Meanwhile, IFN γ is expressed in activated T cells, such as Th1 cells, and also plays a crucial role in immune system. Beside the immune roles, IFNs were demonstrated to regulate bone homeostasis via osteoclasts, osteoblasts or both. In this review, I will discuss the roles of IFNs in bone system.
Document emailed within 1 workday
Related Documents
Koyama, S.; Narita, M. 1988: In vitro effects of interferon-alpha and interferon-gamma on hematopoietic progenitor cells in bone marrow Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 51(8): 1540-1549Orlova, T.G.; Zhdanova, L.V.; Mentkevich, L.M.; Shcheglovitova, O.N.; Solov'ev, V.D. 1979: Interferon-producing activity of bone marrow cells treated with mRNA for interferon when transplanted to irradiated mice Voprosy Virusologii 5: 541-544
Solov'ev, V.D.; Mentkevich, L.M.; Shcheglovitova, O.N.; Orlova, T.G. 1972: Bone marrow interferon of mice Biulleten' Eksperimental'noi Biologii i Meditsiny 73(5): 74-77
Balan, V.; Nelson, D.R.; Sulkowski, M.S.; Everson, G.T.; Lambiase, L.R.; Wiesner, R.H.; Dickson, R.C.; Garcia, A.; Moore, P.A.; Yu, R.; Subramanian, G.M. 2006: Modulation of interferon-specific gene expression by albumin-interferon-alpha in interferon-alpha-experienced patients with chronic hepatitis C Antiviral Therapy 11(7): 901-908
Pérez Castrillón, J.L.; Cano-del Pozo, M.; Sanz-Izquierdo, S.; Velayos-Jiménez, J.; Dib-Wobakin, W. 2003: Bone mineral density in patients with multiple sclerosis: the effects of interferon Revista de Neurologia 36(10): 901-903
L'vovskiĭ, E.A.; Kiselev, P.N.; Tendler, E.V.; Tokarevich, N.K.; Turbina, I.L. 1974: Formation of interferon in cultures of bone marrow and peripheral blood cells in lymphogranulomatosis Voprosy Onkologii 20(10): 84-85
McGlave, P.; Mamus, S.; Vilen, B.; Dewald, G. 1987: Effect of recombinant gamma interferon on chronic myelogenous leukemia bone marrow progenitors Experimental Hematology 15(4): 331-335
Inglot, A.D.; Piasecki, E.; Szulc, B.; Groehlich, B.; Dobracki, W.; Gładysz, A.; Leszek, J.; Szklarz, E.; Sciborski, R. 1988: Assessment of interferon production in patients with chronic nonviral diseases by whole blood or whole bone marrow techniques Archivum Immunologiae et Therapiae Experimentalis 36(4): 439-446
Brok, H.P.; Heidt, P.J.; van der Meide, P.H.; Zurcher, C.; Vossen, J.M. 1993: Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice Journal of Immunology 151(11): 6451-6459
Szulc, B.; Inglot, A.D.; Szulc, Z.; Młochowski, J. 1985: Competition of sodium salt of 9-oxo-10-acridineacetic acid with analogs during induction of interferon in the mouse bone marrow-derived macrophages Archivum Immunologiae et Therapiae Experimentalis 33(2): 287-297
Kitagawa, M.; Saito, I.; Kuwata, T.; Yoshida, S.; Yamaguchi, S.; Takahashi, M.; Tanizawa, T.; Kamiyama, R.; Hirokawa, K. 1997: Overexpression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma by bone marrow cells from patients with myelodysplastic syndromes Leukemia 11(12): 2049-2054
Lepri, E.; Delfino, D.V.; Migliorati, G.; Moraca, R.; Ayroldi, E.; Riccardi, C. 1998: Functional expression of Fas on mouse bone marrow stromal cells: upregulation by tumor necrosis factor-alpha and interferon-gamma Experimental Hematology 26(13): 1202-1208
Abdulkadyrov, K.M.; Rukavitsyn, O.A.; Moiseev, S.I.; Rugal', V.I. 1993: A comparative analysis of the effect of alpha 2-interferon (reaferon) therapy on the morphofunctional state of the bone marrow in patients with chronic myeloleukemia Gematologiia i Transfuziologiia 38(3): 11-13
Shinohara, K.; Tanaka, M.; Matsuda, M.; Tanaka, H.; Fujii, Y.; Yamada, K.; Kaneko, T. 1990: Gamma interferon production and two-color fluorescence flow cytometry analysis of peripheral blood mononuclear cells in allogeneic bone marrow transplant recipients Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 53(1): 76-83
Lvovsky, E.A.; D'Souza, J.; Eng, D.; D'Souza, D.; Lvovsky, B.; Hetland, R.; Craver, W.L.; Sobel, S.H. 1988: Tumor response to interferon inducer and radiation effect of serum interferon levels Journal of Biological Regulators and Homeostatic Agents 2(1): 1-6
Akimoto, M.; Ueki, H.; Nakajima, Y.; Matano, S.; Ewasaki, H.; Abe, R.; Kasai, M. 1984: Prevention of 5-FU induced toxicity in C3 H/HE mice with interferon or with interferon inducers (poly 1: C, OK-432, Lentinan) Gan to Kagaku Ryoho. Cancer and ChemoTherapy 11(7): 1462-1467
Günther, G.; Otto, B. 1993: Interferon. An overview of the state of basic research with special regard to interferon-gamma Arzneimittel-Forschung 43(2): 182-188
Sumpio, B.E.; Ernstoff, M.S.; Kirkwood, J.M. 1984: Urinary excretion of interferon, albumin, and beta 2-microglobulin during interferon treatment Cancer Research 44(8): 3599-3603
Meager, A.; Parti, S.; Webb, K.; Exley, T. 1986: Development of interferon-specific monoclonal antibody for in vitro interferon assays Developments in Biological Standardization 64: 237-248
Gutman, N.R.; Manakhova, L.S. 1981: Ability of influenza virus strains to induce interferon and their sensitivity to the action of exogenous interferon Voprosy Virusologii 2: 168-171