Design and synthesis of photoaffinity biotin labelled 2'-O-propargyl-guanosine
Na, L.-x.; Liu, X.; Meng, Z.-m.; Guan, Z.; Zhang, L.-h.; Yang, Z.-j.
Yao Xue Xue Bao 50(1): 59-63
2015
ISSN/ISBN: 0513-4870 PMID: 25924476 Document Number: 684955
Photoaffinity labeling is widely applied to demonstrate targets of small molecule ligands. In this paper, biotin photoaffinity labeled molecule with propargyl group 1 has been designed and synthesized, followed it's labeling of N2-acetyl-2'-O-propargyl guanosine 9 by "click chemistry". This technology presents delight development potential in labeling of second messenger cyclic nucleotide, antisense oligonucleotide or siRNA.
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