Morphological characteristic dysplastic features on colonic adenomas
Gvamichava, T.; Machavariani, T.; Gachechiladze, I.; Gogiashvili, L.
Georgian Medical News 242: 65-70
2015
ISSN/ISBN: 1512-0112 PMID: 26042450 Document Number: 684333
Morphological changes of tubular adenomas with severe dysplasia are charachterized by low level of cytodifferentiation, epithelial cells intensive proliferation, detected by 3Н-Thymidine and markedly reduction of goblet cells. Functional activity of tumor parenchyma decreases with change in ATP-ase activity. The quantity of young form fibroblasts is markedly increased in adenomous stroma, which caused a disturbance of fibrillogenesis. The local immunologic response was suppressed, the activity of T-suppressors was increased. The morphology of endotheliocytes and vascular network was changed. It is concluded that, adenomas with severe dysplasia are the risk factors for the carcinoma "in situ" development; microadenomas and adenomas are the essence of a single pathological process based on dysplastic changes. It is suggested that colonic microadenomas, are the causes the rudiments of forthcoming adenoma, and in some cases may lead to malignization.