Effectiveness and safety of antiviral therapy of military personnel suffering from chronic hepatitis C
Zhdanov, K.V.; Gusev, D.A.; Kozlov, K.V.; Shishkin, M.K.; Sukachev, V.S.; Shakhmanov, D.M.; Zhabrov, S.S.
Voenno-Meditsinskii Zhurnal 336(4): 44-49
2015
ISSN/ISBN: 0026-9050 PMID: 26454938 Document Number: 682954
In order to evaluate effectiveness and safety of antiviral therapy schemes examined and treated 191 patients with chronic bepatitis C were assigned standard interferon and ribavirin, pegslated interferon and ribavirin, the total duration of the course coput 24-48 weeks. Based on clinical and laboratory parameters evaluated the safety of antiviral therapy. Formation of sustainable viral response, depending on the genotype observed, was given at 58,9-70%.of patients. In case of insufficient. antiviral therapy was prescribed a second course that will improve the effectiveness of treatment to 90-95%. Correction of adverse events was held lower dosages of interferon and/or ribavirin.