Polymorphism of Gluthatione-S-Transferase P1 in Children with Reflux-Esophagitis
Zagorskiy, S.E.; Melnov, S.B.; Sinevich, E.A.
Likars'ka Sprava 2015(1-2): 134-135
2015
ISSN/ISBN: 1019-5297 PMID: 26118046 Document Number: 682445
The distribution of allele and genotype frequencies of genes of xenobiotic detoxication (CYP2E1--PstI, RsaI, DraI; ADH, ALDH, NAT2, GSTP1, GSTM1, GSTT1) was examined in 147 patients with reflux-esophagitis (RE) and 50 conditionally healthy children 12-18 years. The frequency of AA genotype of GSTP1 gene and A allele was significantly higher in patients with RE as compared with healthy children (χ2 = 4.93; P = 0.03 and χ2 = 5.94; P = 0.01 respectively).