Basic Principles of Lyophilization, Part 1
Akers, M.J.
International Journal of Pharmaceutical Compounding 19(6): 471-476
2015
ISSN/ISBN: 1092-4221 PMID: 26891561 Document Number: 682444
The achievement of a high-quality lyophilized (freeze-dried) dosage form involves the combination of optimal formulation design and optimal freeze-dry cycle design. This 2-part article describes how this can be done. Part 1 discusses the basic principles and procedures of lyophilization up to a discussion on the different stages of lyophilization. The stages of lyophilization are discussed in part 2.