Radical prostatectomy and radiation therapy for high-risk prostate cancer: An update
Lei, J-hao.; Chen, Y-ji.; Liu, L-ren.; Wei, Q.
Zhonghua Nan Ke Xue 21(7): 663-666
2015
ISSN/ISBN: 1009-3591 PMID: 26333232 Document Number: 682174
Recently, the D'Amico classification system is widely used for the risk stratification of prostate cancer (PCa) , although no consensus has been reached for the definition of high-risk PCa. This system defines high-risk PCa as a prostate-specific antigen (PSA) level > 20 ng/ml, a Gleason score of 8-10, or a clinical stage ≥ T2c. Because high-risk PCa is prone to recurrence and metastasis after treatment, a proper initial therapy plays a crucial role. Currently, radical prostatectomy and radiation therapy are considered to be two most important options for the initial treatment of high-risk PCa although it remains controversial which is better.