Fixed drug eruption from amoxycillin
Jiménez, I.; Antón, E.; Picáns, I.; Sánchez, I.; Quiñones, M.D.; Jerez, J.
Allergologia et Immunopathologia 25(5): 247-248
1997
ISSN/ISBN: 0301-0546 PMID: 9395009 Document Number: 6815
We present a case of fixed drug eruption on the genital mucosa induced by amoxycillin. Topical provocation was carried out, applying amoxycilin (10% pet) on the glans penis. No reaction was observed. Oral challenge with amoxycillin was followed by pruritic erythema on the glans penis 6 hours after the intake of 125 mg. The study of cross-reactivity to other betalactams showed good tolerance of phenoxymethyl-penicillin, which shares an identical nuclear structure with amoxycillin. The patient also tolerated cephadroxil, a cephalosporin with a side chain identical to that of amoxycillin. On reviewing the literature we have only found three reports of fixed drug eruption fue to amoxycillin.
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