Anxiety and Polymorphism Val66Met of BDNF gene Predictors of Depression Severity in Ischemic Heart Disease
Golimbet, V.E.; Volel, B.A.; Kopylov, F.Y.; Dolzhikov, A.V.; Korovaitseva, G.I.; Kasparov, S.V.; Isaeva, M.I.
Kardiologiia 55(1): 9-13
2015
ISSN/ISBN: 0022-9040 PMID: 28294821 Document Number: 681146
In a framework of search for early predictors of depression in patients with ischemic heart disease (IHD) we studied effect of molecular- genetic factors (polymorphism of brain-derived neirotrophic factor - BDNF), personality traits (anxiety, neuroticism), IHD severity, and psychosocial stressors on manifestations of depression in men with verified diagnosis of IHD. Severity of depression was assessed by Hamilton Depression Rating Scale 21-Item (HAMD 21), anxiety and neuroticism were evaluated by the Spielberger State-Trait Anxiety Inventory and "Big Five" questionnaire, respectively. It was shown that personal anxiety and ValVal genotype of BDNF gene appeared to be predictors of moderate and severe depression.