Protein Interaction Network Construction and Biological Pathway Analysis Related to Atherosclerosis
Li, Q.; Gu, S.; Li, N.; Li, Z.; Lai, W.; Zeng, Y.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 32(6): 1255-1260
2015
ISSN/ISBN: 1001-5515 PMID: 27079097 Document Number: 681031
Atherosclerosis is a complex disease characterized by lipid accumulation in the vascular wall and influenced by multiple genetic and environmental factors. To understand the mechanisms of molecular regulation related to atherosclerosis better, a protein interaction network was constructed in the present study. Genes were collected in nucleotide database and interactions were downloaded from Biomolecular Object Network Database (BOND). The interactional data were imported into the software Cytoscape to construct the interaction network, and then the degree characteristics of the network were analyzed for Hub proteins. Statistical significance pathways and diseases were figured out by inputting Hub proteins to KOBAS2. 0. The complete pathway network related to atherosclerosis was constructed. The results identified a series of key genes related to atherosclerosis, which would be the potential promising drug targets for effective prevention.