Features of functional activity of dendritic cells in tumor growth
Sennikov, S.V.; Obleukhova, I.A.; Kurilin, V.V.; Kulikova, E.V.; Khristin, A.A.
Voprosy Onkologii 61(4): 556-562
2015
ISSN/ISBN: 0507-3758 PMID: 26571822 Document Number: 680655
During recent years much data, accumulated on biology, function and role of dendritic cells (DC) in cancer development, in a new way allow assessing their role in disease process. Identification of features of DC functional state as well as their interaction and influence on the immune cells in tumor growth can be used as a basis for a new approach to cancer therapy enhancing standard therapy efficacy. The review analyzes different mechanisms of escaping of tumor cell from immune surveillance involving DC as one of the main participants of antitumor immune response. Also the prospects of using DC for vaccination are discussed. DC can be promising target for therapeutic strategies and also can be used for formation of antitumor response and cell therapy.