Comparison of Biological Difference between Bone Marrow and Placenta-Derived Mesenchimal Stem cells in Hypoxia
Xia, B.; Tan, M.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 29(1): 103-107
2015
ISSN/ISBN: 1002-1892 PMID: 26455181 Document Number: 679592
To comprehensively analyze and compare the biological difference between bone marrow mesenchymal stem cells (BMSCs) and placenta-derived MSCs (PMSCs) in hypoxia and to extend the knowledge for seed cells selection. The domestic and foreign related literature about the effects of hypoxia microenvironment on proliferation, apoptosis, differentiation, paracrine secretion, migration, and homing ability of BMSCs and PMSCs were summarized and analysed. PMSCs proliferated much faster and more sensitive to the hypoxia than BMSCs; in addition, PMSCs showed stronger survivability. Similar to BMSCs, PMSCs can home to hypoxic-ischemic tissues efficiently, secrete a lot of growth factors and differentiate into tissue-specific cells to stimulate tissue regeneration. PMSCs as the seed cells will have broad application prospects in the regenerative medicine.