Conformational preferences of chiral acyclic homooligomeric β (2,2) -peptides
Rodriguez, F.; Corzana, F.; Avenoza, A.; Busto, J.Hector.; Peregrina, J.Manuel.; Zurbano, M.Del.Mar.
Current Topics in Medicinal Chemistry 14(10): 1225-1234
2014
ISSN/ISBN: 1568-0266 PMID: 24758434 Document Number: 678276
α-Methylisoserine, a chiral acyclic quaternary β-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous β(2,2)-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of β-turn.
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