Relationship between carotid intima thickness and silent cerebral infarction in patients with type 2 diabetic nephropathy
Kumar, D.; Agarwal, S.; Karoli, R.; Siddiqui, M.; Shukla, V.; Khanduri, S.
Journal of the Association of Physicians of India 62(4): 316-322
2014
ISSN/ISBN: 0004-5772 PMID: 25327034 Document Number: 677808
To examine the relationship between carotid intima media thickness (CIMT) and silent cerebral infarction (SCI) in order to determine whether CIMT is a predictor of SCI in patients of type 2 diabetic nephropathy. A total of 80 patients of type 2 diabetic nephropathy were selected on the basis of fasting and 2-hour post-prandial blood sugar, 24 hrs albumin estimation in urine, urea and creatinine in the serum. The selected candidates underwent MRI brain and carotid B mode ultrasonography to find out the event of SCI and to evaluate the CIMT respectively. The SCI was found in 30 (37.5%) patients with type 2 diabetic nephropathy. The mean age, BMI, blood pressure (BP), macroalbuminuria, S. lipids, low GFR, duration of diabetes and CIMT were significantly higher in the subject with SCI than in those without it. Multiple logistic analyses indicated that age, BP, and CIMT were found to be significant and independent risk factors of SCI in type 2 diabetic nephropathy subjects. CIMT is a surrogate and reliable predictor of higher risk of SCI among type 2 diabetic nephropathy patients.