Increased Soluble OX40L is Associated with Carotid Intima-Media Thickness
Dao-Peng, Q.; Huang, S.; Shu-Yuan, G.; Shui-Ping Zhao
Clinical Laboratory 56(9-10): 449-457
2010
ISSN/ISBN: 1433-6510 PMID: 21086790 Document Number: 13107
Background: Recent studies indicated that soluble OX40 ligand (OX40L) levels were increased in acute coronary syndrome. But the association between sOX40L and carotid intima-media thickness (IMT) has not been evaluated. Methods: We measured plasma soluble OX40L (sOX40L) and Interleukin-10 (IL-10) levels in 35 patients with stable angina pectoris, 30 patients with risk factors of coronary artery disease, and 20 age and sex-matched controls. Carotid (IMT) was measured by B-mode ultrasound. Results: Plasma sOX40L levels were positively correlated with Carotid IMT (r = 0.376, P = 0.001) and inversely correlated with IL-10 (P = -0.394, P = 0.000). Multivariate linear regression analysis revealed that sOX40L (p = 0.019) was an independent predictor for Carotid IMT progression after adjusting for the classical cardiovascular risk factors. Conclusions: sOX40L is independently related to Carotid IMT, suggesting the possible relationship of OX40L to atherosclerosis. The positive relation of sOX40L to C-reactive protein (CRP) and the negative relation to IL-10 indicated the possible proinflammatory effects of OX40L on the pathogenesis of atherosclerois.
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