Experimental study of therapeutical properties and safety of king crab collagenase-containing ointment
Sandakhchiev, L.S.; Stavskiĭ, E.A.; Zinov'ev, V.V.; Nazarov, V.P.; Renau, I.V.; Satrikhina, T.N.; Katkova, L.R.; Krinitsin, L.A.; Kolesnikova, L.V.; Taranov, O.S.; Omigov, V.V.; Ovechkina, L.G.; Markovich, N.A.; Malygin, E.G.; Danilenko, E.D.; Voevoda, T.V.; Fedosova, L.K.; Sizova, L.I.; Masycheva, V.I.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 4: 50-55
1998
ISSN/ISBN: 0869-6047 PMID: 9633243 Document Number: 6776
The effects of ointment containing king crab (Paralithodes camtschatica) collagenase on intact skin, thermal, and pyonecrotic wounds were studied in rats by using hematological, biochemical, immunological, and morphological methods. The ointment for the skin and viscera was shown to be safe. It is highly effective in debriding the infected wounds. Different concentrations of collagenase were tested. The concentration of collagenase was recommended to be 0.2 mg/g ointment for use.
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