Is PCi effective in predicting prognosis in the era of oxaliplatin-based chemotherapy in stage IV colorectal cancer with peritoneal dissemination ?
Hatano, S.; Matsuzawa, T.; Chika, N.; Tajima, Y.; Watanabe, Y.; Fukuchi, M.; Baba, H.; Kumagai, Y.; Ishibashi, K.; Mochiki, E.; Ishida, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 41(12): 1692-1694
2014
ISSN/ISBN: 0385-0684 PMID: 25731298 Document Number: 676524
Peritoneal dissemination is expected to be present in P1, P2, and P3 according to the 8th edition of colon cancer handling convention. The peritoneal carcinomatosis index (PCI) plays a central role in classification of peritoneal metastases. Peritoneal dissemination was examined during surgery in patients with colon cancer and peritoneal metastasis undergoing treatment with oxaliplatin-based chemotherapy. Correlation between PCI and P1, P2, and P3 was found. Moreover, using a PCI cut-off value of 6 for peritoneal dissemination, there was a significant difference in survival. Positive correlation was found between PCI and P classification of colon cancer. Regardless of the presence metastases to other organs, there is a possibility that PCI is effective in predicting prognosis of patients with peritoneal dissemination- positive colon cancer.