Muscle weakness in treatment of palmar hyperhidrosis with botulinum toxin type a: can it be prevented?
Kouris, A.; Vavouli, C.; Markantoni, V.; Kontochristopoulos, G.
Journal of Drugs in Dermatology Jdd 13(11): 1315-1316
2014
ISSN/ISBN: 1545-9616 PMID: 25607695 Document Number: 675682
Palmar hyperhidrosis is a chronic disorder, resistant to conventional treatment. Clinical studies suggest the effectiveness of botulinum toxin A in the treatment of primary palmar hyperhidrosis. To evaluate the efficacy of botulinum toxin A in the therapy of palmar hyperhidrosis and the frequency of incurred muscle weakness. Four hundred seventy-four patients with palmar hyperhidrosis were enrolled in the study. The Hyperhidrosis Disease Severity Scale (HDSS) and the Minor-iodine starch test were chosen to assess the disease severity. In addition, a physician's global assessment scale was used to evaluate the effectiveness of the treatment with BTX-A. There were 312 females and 162 males aged 19-48 (mean 29 years). The improvement following the injection at two weeks and at one, three, six and nine months, as evaluated by physicians, was 82%, 83%, 74%, 48% and 28%, respectively. Two hundred and seventy five patients reported local pain and muscle weakness occurred in 102 patients. BTX-A led to the reduction of disease severity while transient side effects were reported.