The frequency-contrast sensitivity of visual stimulus perception in patients with schizophrenia with the therapy of atypical and typical antipsychotic drugs
Shoshina, I.I.; Shelepin, I.E.; Semenova, N.B.
Fiziologiia Cheloveka 40(1): 43-48
2014
ISSN/ISBN: 0131-1646 PMID: 25272767 Document Number: 675258
We studied the effect of typical and atypical antipsychotics drag treatment on the perception of visual stimulus which activates preferentially different visual channels. We recorded contrast sensitivity in normal and schizophrenic patients. Elements presented with Gabor-like gratings with sinusoidal distribution of brightness, spatial frequency: 0.4 cycles/degree, 3.6 and 17.9 cycles/degree. Patients were divided into two groups. One group--patients treated with atypical antipsychotics, and the second group--patients treated with typical antipsychotics drags. Registered a decline compared with the normal contrast sensitivity for low and medium spatial frequencies. We observed significant difference between two groups of patients in the range of low spatial frequencies.